Article

SPTBN2 promotes an immunosuppressive tumor microenvironment and cross-resistance to anti-cancer therapies

2026-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Immunosuppressive tumor microenvironment (TME) inactivates CD8+ cytotoxic lymphocytes (CTLs). Here, we identify SPTBN2 spectrin as a key immunosuppressive regulator induced in CTLs in response to nutritional deficit. In human pancreatic and colorectal cancers, SPTBN2 expression negatively correlated with CTL infiltration and patients’ survival. In TME of mouse pancreatic and colorectal adenocarc...

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Literature Corpus work: 95e18b8b-959f-5acb-8258-d13d011b5a3e
DOI: 10.64898/2026.03.30.715365

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