Contrasting roles of PSGL-1 and PD-1 in regulating T-cell exhaustion and function during chronic viral infection

Abstract excerpt

ABSTRACT Immune checkpoints are critical regulators of T-cell exhaustion, impairing their ability to eliminate antigens present during chronic viral infections. Current immune checkpoint inhibitors (ICIs) used in the clinic aim to reinvigorate exhausted T cells; yet, most patients fail to respond or develop resistance to these therapies, underscoring the need to better understand these immunosuppressive pathways....

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