Article

Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Cholesterol imbalance is a hallmark of major human diseases, including atherosclerosis and Alzheimer’s disease, both of which are also associated with mitochondrial dysfunction, yet the mechanistic links between cholesterol and mitochondria remain poorly understood. Here we show that elevated intracellular cholesterol in murine astrocytes expressing the Alzheimer’s disease risk variant APOE4 di...

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Literature Corpus work: 7218d5c9-50dc-553e-9e23-994921ab932d
DOI: 10.64898/2026.08.04.742391

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