Article

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilization

2026-05-23

Abstract excerpt

α-Lipoic acid (LA) is widely included in “mitochondrial cocktails” recommended to patients with primary mitochondrial disorders, yet its mechanism of action remains unclear. Here, we define the intracellular availability and functional utilization of LA in mammalian cells. We show that LA exists in two functionally distinct cellular pools: a low-abundance free pool and a protein-bound pool generated through mitoch...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee699a9f-fd2d-545b-9a9d-3f1a4cf5de3e
DOI: 10.64898/2026.05.22.727209

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Functional partitioning of lipoic acid decouples cellular abundance from mitochondrial utilizationDOI 10.64898/2026.05.22.727209Read

Mitochondrial fatty acid synthesis is essential for coordinated energy transformationSemantic proximity Read

A Multi-target Pharmacological Correction of a Lipoyltransferase LIPT1 Gene Mutation in Patient-Derived Cellular ModelsSemantic proximity Read

Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammationSemantic proximity Read

Energy metabolism adaptations and gene expression reprogramming in a cellular MAFLD modelSemantic proximity Read

Small molecule promoters of endogenous lipid droplet accumulation drive lysophagySemantic proximity Read

Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death.Semantic proximity Read

The functions of cardiolipin in cellular metabolism-potential modifiers of the Barth syndrome phenotype.Semantic proximity Read

Fatty acid metabolic interactome atlas linked to cellular longevitySemantic proximity Read

Expression of human monolysocardiolipin acyltransferase-1 improves mitochondrial function in Barth syndrome lymphoblasts.Semantic proximity Read

Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunctionSemantic proximity Read

Mitochondrial Genetic Disorders: Cell Signaling and Pharmacological TherapiesSemantic proximity Read

Increased antioxidant response in medium-chain acyl-CoA dehydrogenase deficiency: does lipoic acid have a protective role?Semantic proximity Read