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Article

Exploring mitochondrial cholesterol signalling for therapeutic intervention in neurological conditions

11 May 2019

Abstract excerpt

The pharmacological targeting of cholesterol levels continues to generate interest due to the undoubted success of therapeutic agents, such as statins, in extending life expectancy by modifying the prognosis of diseases associated with the impairment of lipid metabolism. Advances in our understanding of mitochondrial dysfunction in chronic age-related diseases of the brain have disclosed an emerging role for...

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PMID: 31077345
DOI: 10.1111/bph.14697

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