Article

Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis

2024-10-10

Abstract excerpt

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder marked by lipid accumulation, leading to metabolic dysfunction-associated steatohepatitis (MASH). A key feature of the transition to MASH involves oxidative stress resulting from defects in mitochondrial oxidative phosphorylation (OXPHOS). Here, we show that pathological alterations in the lipid composition of the inner mito...

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Identifiers and source

Literature Corpus work: 04c70211-ecbe-5c1a-8923-b3af4cac7c6b
DOI: 10.1101/2024.10.10.617517

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