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Liver zonation, revisited

17 Feb 2022

Abstract excerpt

The concept of hepatocyte functional zonation is well established, with differences in metabolism and xenobiotic processing determined by multiple factors including oxygen and nutrient levels across the hepatic lobule. However, recent advances in single-cell genomics technologies, including single-cell and nuclei RNA sequencing, and the rapidly evolving fields of spatial transcriptomic and proteomic profiling...

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PMID: 35175659
DOI: 10.1002/hep.32408

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