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Article

Hepatic zonation determines tumorigenic potential of mutant β-catenin.

Nature - 1 Jan 2026

Raven Alexander, Gilroy Kathryn, Jin Hu, Waldron Joseph A, Leslie Holly, Munro June, Hall Holly, Ridgway Rachel A, Ford Catriona A, Gulhan Doga C, Vlahov Nikola, Mills Megan L, Hartley Andrew, Anderson Eve, Bryson Sheila, Sphyris Nathalie, Müller Miryam, May Stephanie, Cadden Barbara, Nixon Colin, Waddell Scott H, Guest Rachel, Boulter Luke, Barker Nick, Clevers Hans, Zhu Hao, Ivaska Johanna, Strathdee Douglas, Miller Crispin J, Jamieson Nigel B, Bushell Martin, Park Peter J, Bird Thomas G, Sansom Owen J

Abstract excerpt

Oncogenic mutations in phenotypically normal tissue are common across adult organs1,2. This suggests that multiple events need to converge to drive tumorigenesis and that many processes such as tissue differentiation may protect against carcinogenesis. WNT-β-catenin signalling maintains zonal differentiation during liver homeostasis3,4. However, the CTNNB1 oncogene-encoding β-catenin-is also frequently mutated in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41261129
DOI: 10.1038/s41586-025-09733-1
PMCID: PMC12804091

Genes

MYC
CTNNB1
IGFBP2
GLUL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

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Hepatic zonation determines tumorigenic potential of mutant β-catenin.PMID 41261129Read ↗

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