Article
A novel liver zonation phenotype-associated molecular classification of hepatocellular carcinoma.
Frontiers in immunology - 1 Jan 2023
Zhang Tao, Gu Jian, Wang Xinyi, Lu Yaoyao, Cai Kailin, Li Huili, Nie Yingli, Chen Xiangdong, Wang Jiliang
Abstract excerpt
Background: Liver zonation is a unique phenomenon in which the liver exhibits distinct functions among hepatocytes along the radial axis of the lobule. This phenomenon can cause the sectionalized initiation of several liver diseases, including hepatocellular carcinoma (HCC). However, few studies have explored the zonation features of HCC. Methods: Four single-cell RNA sequencing datasets were used to identify...
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