Article
The origin of hepatocellular carcinoma depends on metabolic zonation.
Science (New York, N.Y.) - 29 Jan 2026
Guo Jason, Liang Roger, Chung Andrew, Li Zhijie, Li Boyuan, Chen Eric, Li Lin, Wang Jingjing, Hsieh Meng-Hsiung, Fang Ivy Xiangyi, Kroger Benjamin, Wang Yunguan, Zhu Min, Ren Xiongzhao, Mannino Greg, Jia Yuemeng, Wei Yonglong, Moore Stephen, Siegwart Daniel J, Chung Stephen S, Wang Zixi, Sharma Tripti, Komjeti Suman, Han Yi, Gopal Purva, Xiao Guanghua, Wang Tao, Zhu Hao
Abstract excerpt
The origin of cancer is poorly understood because premalignant cells are rarely followed in their native environments. Although the spatial compartmentalization of metabolic functions is critical for proper liver function, it is unknown whether cancers arise from some zones but not others and whether there are metabolic determinants of cancer risk. Zone-specific, mosaic introduction of Ctnnb1 (catenin beta 1) and...
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