Article

Deciphering the Multiscale Morphology of Somatic Oncogenic Alterations in Hepatocellular Carcinoma

2026-07-16

Abstract excerpt

Somatic oncogenic mutations are typically defined by their molecular alterations, yet how they reorganize cellular architecture within intact tissues remain largely unknown. Here, we demonstrate that distinct oncogenic drivers produce unique multiscale architectural phenotypes that can be quantitatively resolved in intact liver tissue. Using iterative expansion microscopy, multiscale light-sheet imaging, and three...

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Literature Corpus work: 96fb3ac7-83bf-5dee-adcd-b45c8de5331c
DOI: 10.64898/2026.07.15.738764

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