Article

Spatial single-cell interactome and niche-specific molecular signatures in alcohol-related liver disease

2025-03-17

Abstract excerpt

Alcohol-related liver disease (ALD) remains a major global health burden with limited therapeutic options due to an incomplete understanding of its underlying molecular mechanisms and cellular crosstalk. Here, we applied ultra-high resolution (on 2 µm spots) spatial transcriptomics to a cirrhotic liver tissue obtained from an end-stage ALD patient, analyzing >265,000 spatially resolved cells with further validatio...

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Literature Corpus work: 51fe3ec2-484d-5c25-869a-83096d42ddac
DOI: 10.1101/2025.03.15.643421

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