Article
Genome-wide meta-analysis identifies 93 risk loci and enables risk prediction equivalent to monogenic forms of venous thromboembolism.
Nature genetics - 1 Mar 2023
Ghouse Jonas, Tragante Vinicius, Ahlberg Gustav, Rand Søren A, Jespersen Jakob B, Leinøe Eva Birgitte, Vissing Christoffer Rasmus, Trudsø Linea, Jonsdottir Ingileif, Banasik Karina, Brunak Søren, Ostrowski Sisse R, Pedersen Ole B, Sørensen Erik, Erikstrup Christian, Bruun Mie Topholm, Nielsen Kaspar Rene, Køber Lars, Christensen Alex H, Iversen Kasper, Jones David, Knowlton Kirk U, Nadauld Lincoln, Halldorsson Gisli H, Ferkingstad Egil, Olafsson Isleifur, Gretarsdottir Solveig, Onundarson Pall T, Sulem Patrick, Thorsteinsdottir Unnur, Thorgeirsson Gudmundur, Gudbjartsson Daniel F, Stefansson Kari, Holm Hilma, Olesen Morten Salling, Bundgaard Henning
Abstract excerpt
We report a genome-wide association study of venous thromboembolism (VTE) incorporating 81,190 cases and 1,419,671 controls sampled from six cohorts. We identify 93 risk loci, of which 62 are previously unreported. Many of the identified risk loci are at genes encoding proteins with functions converging on the coagulation cascade or platelet function. A VTE polygenic risk score (PRS) enabled effective...
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