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Article

Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.

Blood advances - 14 Oct 2025

Wolford Brooke N, Zhao Queena Yakun, Wu Kuan-Han H, Yu Xinge, Richter Catherine E, Bhatta Laxmi, Brumpton Ben M, Desch Karl C, Thibord Florian, Klarin Derek, Johnson Andrew D, Trégouët David-Alexandre, Damrauer Scott M, Smith Nicholas L, Lo Faro Valeria, Tsuo Kristin, Daly Mark J, Neale Benjamin M, Zhou Wei, Willer Cristen J, Shavit Jordan A, Surakka Ida

Abstract excerpt

ABSTRACT: Venous thromboembolisms (VTEs) are a leading cause of morbidity and mortality. Although many genetic risk factors have been identified, a substantial portion of the heritability remains unexplained. In this study, we employed a genome-wide association study (GWAS) for VTE across 9 international cohorts of the Global Biobank Meta-Analysis Initiative to address this question, along with in vivo functional...

Topics

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Disease Models, Animal
VWF gene
Genetic Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Venous Thromboembolism

Source

Open in PubMed Open full text

Identifiers

PMID: 40554366
DOI: 10.1182/bloodadvances.2024015790
PMCID: PMC12495096

Genes

TC2N
RASIP1
STAB2
TSPAN15
F11
F5
F7
PLCG2
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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