Article
Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.
PLoS genetics - 1 Sept 2018
Tomberg Kärt, Westrick Randal J, Kotnik Emilee N, Cleuren Audrey C, Siemieniak David R, Zhu Guojing, Saunders Thomas L, Ginsburg David
Abstract excerpt
Although the Factor V Leiden (FVL) gene variant is the most prevalent genetic risk factor for venous thrombosis, only 10% of FVL carriers will experience such an event in their lifetime. To identify potential FVL modifier genes contributing to this incomplete penetrance, we took advantage of a perinatal synthetic lethal thrombosis phenotype in mice homozygous for FVL (F5L/L) and haploinsufficient for tissue...
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