Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2017

Zhu Qiuyu Martin, Ko Kyung Ae, Ture Sara, Mastrangelo Michael A, Chen Ming-Huei, Johnson Andrew D, O'Donnell Christopher J, Morrell Craig N, Miano Joseph M, Lowenstein Charles J

Abstract excerpt

OBJECTIVE: To identify and characterize the effect of a SNP (single-nucleotide polymorphism) in the STXBP5 locus that is associated with altered thrombosis in humans. GWAS (genome-wide association studies) have identified numerous SNPs associated with human thrombotic phenotypes, but determining the functional significance of an individual candidate SNP can be challenging, particularly when in vivo modeling is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation
Share to Clustered Regularly Interspaced Short Palindromic Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CRISPR-Associated Proteins

Share to Exocytosis

Share to Platelet Activation

Share to R-SNARE Proteins

Share to Thrombosis

Share to von Willebrand Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 28062498
DOI: 10.1161/ATVBAHA.116.308614
PMCID: PMC5269475

Genes

STXBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.PMID 28062498Read ↗

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor lociSemantic proximity Read ↗

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouseSemantic proximity Read ↗

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.Semantic proximity Read ↗

Genetic dissection of quantitative trait Loci for hemostasis and thrombosis on mouse chromosomes 11 and 5 using congenic and subcongenic strains.Semantic proximity Read ↗

Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafishSemantic proximity Read ↗

Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Semantic proximity Read ↗

Quantitative trait locus analysis for hemostasis and thrombosis.Semantic proximity Read ↗

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleedingSemantic proximity Read ↗

Mice with reduced protease-activated receptor 4 reactivity show decreased venous thrombosis and platelet procoagulant activity.Semantic proximity Read ↗

Genome Sequencing Unveils a New Regulatory Landscape of Platelet ReactivitySemantic proximity Read ↗

A Mouse Model of the Protease Activated Receptor 4 (PAR4) Pro310Leu Variant has Reduced Platelet ReactivitySemantic proximity Read ↗

Characterization of the Platelet Phenotype Caused by a Germline RUNX1 Variant in a CRISPR/Cas9-Generated Murine Model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.