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Article

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci

21 Aug 2017

Abstract excerpt

Significance Venous thromboembolism (VTE) is a common disease characterized by the formation of inappropriate blood clots. Inheritance of specific genetic variants, such as the Factor V Leiden polymorphism, increases VTE susceptibility. However, only ∼10% of people inheriting Factor V Leiden develop VTE, suggesting the involvement of other genes that are currently unknown. By inducing random genetic mutations...

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PMID: 28827327
DOI: 10.1073/pnas.1705762114

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