Article

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse

2017-08-09

Abstract excerpt

Although the Factor V Leiden (FVL) gene variant is the most prevalent genetic risk factor for venous thrombosis, only 10% of FVL carriers will experience such an event in their lifetime. To identify potential FVL modifier genes contributing to this incomplete penetrance, we took advantage of a perinatal synthetic lethal thrombosis phenotype in mice homozygous for FVL ( F5 L/L ) and haploinsufficient for tissue f...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 185e62f1-19a8-53b5-bbe2-6f04ad369b12
DOI: 10.1101/174086

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouseDOI 10.1101/174086Read

Whole exome sequencing of ENU-induced thrombosis modifier mutations in the mouse.Semantic proximity Read

A sensitized mutagenesis screen in Factor V Leiden mice identifies novel thrombosis suppressor lociSemantic proximity Read

Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice.Semantic proximity Read

A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleedingSemantic proximity Read

A sensitized model of thrombosis validates known multigenic relationships and suggests novel modifiers of hemostasisSemantic proximity Read

Multi-ancestry GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafishSemantic proximity Read

Analysis of factor V in zebrafish demonstrates minimal levels needed for hemostasis and risk stratifies human variantsSemantic proximity Read

Modeling Somatic Second-Hit Mutations in Novel Mouse Models of Hereditary Hemorrhagic TelangiectasiaSemantic proximity Read

Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor lociSemantic proximity Read

Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.Semantic proximity Read

Efficient and fast targeted production of murine models based on ENU mutagenesis.Semantic proximity Read

The human knockout phenotype of <i><scp>PADI6</scp></i> is female sterility caused by cleavage failure of their fertilized eggsSemantic proximity Read