Article

Quantitative occupancy of myriad transcription factors from one DNase experiment enables efficient comparisons across conditions

2020-06-29

Abstract excerpt

Over a thousand different transcription factors (TFs) bind with varying occupancy across the human genome. Chromatin immunoprecipitation (ChIP) can assay occupancy genome-wide, but only one TF at a time, limiting our ability to comprehensively observe the TF occupancy landscape, let alone quantify how it changes across conditions. We developed TOP, a Bayesian hierarchical regression framework, to profile genome-wi...

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Literature Corpus work: 71d58b04-6c67-501c-a240-44823c90c7e1
DOI: 10.1101/2020.06.28.171587

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