Article
Architecture of the human regulatory network derived from ENCODE data.
Nature - 6 Sept 2012
Gerstein Mark B, Kundaje Anshul, Hariharan Manoj, Landt Stephen G, Yan Koon-Kiu, Cheng Chao, Mu Xinmeng Jasmine, Khurana Ekta, Rozowsky Joel, Alexander Roger, Min Renqiang, Alves Pedro, Abyzov Alexej, Addleman Nick, Bhardwaj Nitin, Boyle Alan P, Cayting Philip, Charos Alexandra, Chen David Z, Cheng Yong, Clarke Declan, Eastman Catharine, Euskirchen Ghia, Frietze Seth, Fu Yao, Gertz Jason, Grubert Fabian, Harmanci Arif, Jain Preti, Kasowski Maya, Lacroute Phil, Leng Jing Jane, Lian Jin, Monahan Hannah, O'Geen Henriette, Ouyang Zhengqing, Partridge E Christopher, Patacsil Dorrelyn, Pauli Florencia, Raha Debasish, Ramirez Lucia, Reddy Timothy E, Reed Brian, Shi Minyi, Slifer Teri, Wang Jing, Wu Linfeng, Yang Xinqiong, Yip Kevin Y, Zilberman-Schapira Gili, Batzoglou Serafim, Sidow Arend, Farnham Peggy J, Myers Richard M, Weissman Sherman M, Snyder Michael
Abstract excerpt
Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes; the ensemble of these binding events forms a regulatory network, constituting the wiring diagram for a cell. To examine the principles of the human transcriptional regulatory network, we determined the genomic binding information of 119 transcription-related factors in over 450 distinct experiments. We found the...
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