R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.

doi:10.1007/s00401-021-02325-z

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Article

R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.

Acta neuropathologica - 1 Sept 2021

Fan Ying, Nirujogi Raja S, Garrido Alicia, Ruiz-Martínez Javier, Bergareche-Yarza Alberto, Mondragón-Rezola Elisabet, Vinagre-Aragón Ana, Croitoru Ioana, Gorostidi Pagola Ana, Paternain Markinez Laura, Alcalay Roy, Hickman Richard A, Düring Jonas, Gomes Sara, Pratuseviciute Neringa, Padmanabhan Shalini, Valldeoriola Francesc, Pérez Sisqués Leticia, Malagelada Cristina, Ximelis Teresa, Molina Porcel Laura, Martí Maria José, Tolosa Eduardo, Alessi Dario R, Sammler Esther M

Abstract excerpt

Heterozygous gain-of-kinase function variants in LRRK2 (leucine-rich repeat kinase 2) cause 1-2% of all cases of Parkinson's disease (PD) albeit with incomplete and age-dependent penetrance. All pathogenic LRRK2 mutations reside within the two catalytic domains of LRRK2-either in its kinase domai...

Topics

Adult
Aged
Aged, 80 and over
Autopsy
Biomarkers
Female
Heterozygote
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Mutation

Neutrophils

Parkinson Disease

Phosphorylation

Protein Kinase Inhibitors

Protein Processing, Post-Translational

rab GTP-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34125248
DOI: 10.1007/s00401-021-02325-z
PMCID: PMC8357670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-34125248-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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