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Article

Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.

The Biochemical journal - 2 Jan 2018

Fan Ying, Howden Andrew J M, Sarhan Adil R, Lis Pawel, Ito Genta, Martinez Terina N, Brockmann Kathrin, Gasser Thomas, Alessi Dario R, Sammler Esther M

Abstract excerpt

There is compelling evidence for the role of the leucine-rich repeat kinase 2 (LRRK2) and in particular its kinase function in Parkinson's disease. Orally bioavailable, brain penetrant and potent LRRK2 kinase inhibitors are in the later stages of clinical development. Here, we describe a facile and robust assay to quantify LRRK2 kinase pathway activity by measuring LRRK2-mediated phosphorylation of Rab10 in human...

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Identifiers

PMID: 29127255
DOI: 10.1042/BCJ20170803
PMCID: PMC5748842

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.PMID 29127255Read ↗

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