Article

Differences in Somatic TP53 Mutation Type in Breast Tumors by Race and Receptor Status

2021-05-19

Abstract excerpt

<title>Abstract</title> <p><bold>Purpose:</bold> Somatic driver mutations in TP53 are associated with triple negative breast cancer (TNBC) and poorer outcomes. Breast cancers in women of African ancestry (AA) are more likely to be TNBC and have somatic TP53 mutations than cancers in non-Hispanic White (NHW) women. Missense driver mutations in TP53 have varied functional impact including loss-of-function (LOF) or...

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Literature Corpus work: 71cb3416-a0cd-5f59-a624-5fdb49dba34a
DOI: 10.21203/rs.3.rs-268719/v2

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