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Article

Differences in somatic TP53 mutation type in breast tumors by race and receptor status.

Breast cancer research and treatment - 1 Apr 2022

Pollock Nijole C, Ramroop Johnny R, Hampel Heather, Troester Melissa A, Conway Kathleen, Hu Jennifer J, Freudenheim Jo L, Olopade Olufunmilayo I, Huo Dezheng, Ziv Elad, Neuhausen Susan L, Stevens Patrick, McElroy Joseph Paul, Toland Amanda Ewart

Abstract excerpt

PURPOSE: Somatic driver mutations in TP53 are associated with triple-negative breast cancer (TNBC) and poorer outcomes. Breast cancers in women of African ancestry (AA) are more likely to be TNBC and have somatic TP53 mutations than cancers in non-Hispanic White (NHW) women. Missense driver mutations in TP53 have varied functional impact including loss-of-function (LOF) or gain-of-function (GOF) activity, and...

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Identifiers

PMID: 35286522
DOI: 10.1007/s10549-022-06509-3
PMCID: PMC8960361

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