Article

Association of<i>ESR1</i>germline variants with<i>TP53</i>somatic variants in breast tumors in a genome-wide study

2023-12-07

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry. HER2 positive and triple negative breast cancers (TNBC) have a higher frequency of TP53 somatic mutations than other subtypes. PIK3CA mutations are more frequently observed in hormone receptor positive tumors. Emerging data suggest tumor mutation status is associated with germ...

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Literature Corpus work: 1aa985a5-d792-599a-8392-5de5294240e8
DOI: 10.1101/2023.12.06.23299442

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