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Article

Therapeutic landscape in mutational triple negative breast cancer

14 Jul 2018

Abstract excerpt

Triple negative breast cancer (TNBC) is a heterogeneous disease with aggressive behavior and poor prognosis. Genomic sequencing has detected a distinctive mutational portrait of both the germline and somatic alterations in TNBC, which is staggeringly different from other breast cancer subtypes. The clinical utility of sequencing germline BRCA1/2 genes has been well established in TNBC. However, for other...

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PMID: 30007403
DOI: 10.1186/s12943-018-0850-9

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