Article
Mutational landscape of triple-negative breast cancer in African American women.
Nature genetics - 1 Sept 2025
Yao Song, Wei Lei, Hu Qiang, Liu Song, Manojlovic Zarko, Fiorica Peter N, Long Mark, Zirpoli Gary R, Cai Qiuyin, Long Jirong, Ping Jie, Barnard Mollie E, Jin Yuxin, Murakami Mitsuko, Wang Jianmin, Zhu Qianqian, Davis Warren, Chen Jianhong, Ondracek Rochelle P, Khoury Thaer, Gandhi Shipra, Takabe Kazuaki, Ko Naomi, Sanderson Maureen, Hong Chi-Chen, Bandera Elisa V, Craig David W, Ambrosone Christine B, Palmer Julie R, Zheng Wei, Carpten John D
Abstract excerpt
African American (AA) women have the highest incidence of triple-negative breast cancer (TNBC) among all racial groups, but are underrepresented in cancer genomic studies. In 462 AA women with TNBC, we characterized the tumor mutational landscape by whole-exome sequencing and RNA sequencing. We unveiled a high-resolution mutational portrait of TNBC in AA women reminiscent of that in Asian and non-Hispanic white...
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