Article

The nucleolar aberrancies that drive ribosome impairment induced by RNA binding proteins are hallmarks of aging

2023-03-07

Abstract excerpt

The nucleolus is a dynamic structure where ribosome subunits are produced. Indeed, nucleoli respond to any change in cellular homeostasis by altering the rate of ribosome biogenesis, thus working as a stress sensor. Therefore, an imbalance in ribosome biogenesis promotes changes in morphology and function and can evoke a nucleolar stress response. Changes in the structure and composition of nucleoli impair ribosom...

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Literature Corpus work: 47d6d8bf-0e70-57e5-b35c-f03fd1d72b94
DOI: 10.1101/2023.03.07.531270

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