Article

Nucleolar Reorganization After Cellular Stress is Orchestrated by SMN Shuttling between Nuclear Compartments

2022-11-04

Abstract excerpt

<h4>ABSTRACT</h4> SMA is an autosomal recessive neuromuscular disease caused by mutations in the multifunctional protein SMN. Within the nucleus, SMN localizes to Cajal bodies (CBs), which have been shown to be associated with nucleoli, nuclear organelles dedicated to the first steps of ribosome biogenesis. The highly organized structure of the nucleolus can be dynamically altered by genotoxic agents. After genot...

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Literature Corpus work: d66b3aed-ab4e-5ee8-9471-2e167a56a9e8
DOI: 10.1101/2022.11.04.515196

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