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Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels

18 Feb 2010

Abstract excerpt

P-selectin and intercellular adhesion molecule-1 (ICAM-1) participate in inflammatory processes by promoting adhesion of leukocytes to vascular wall endothelium. Their soluble levels have been associated with adverse cardiovascular events. To identify loci affecting soluble levels of P-selectin (sP-selectin) and ICAM-1 (sICAM-1), we performed a genome-wide association study in a sample of 4115 (sP-selectin) and...

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PMID: 20167578
DOI: 10.1093/hmg/ddq061

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