Article

DNMT3A haploinsufficiency results in behavioral deficits and global epigenomic dysregulation shared across neurodevelopmental disorders

2020-07-13

Abstract excerpt

<h4>Summary</h4> Mutations in DNA methyltransferase 3A (DNMT3A) have been detected in autism and related disorders, but how these mutations disrupt nervous system function is unknown. Here we define the effects of neurodevelopmental disease-associated DNMT3A mutations. We show that diverse mutations affect different aspects of protein activity yet lead to shared deficiencies in neuronal DNA methylation. Heterozyg...

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Literature Corpus work: abfd2935-2c77-538d-8a42-f3680d05e2c5
DOI: 10.1101/2020.07.10.195859

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