Article

MeCP2 regulates Gdf11, a dosage-sensitive gene critical for neurological function

2022-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Loss- and gain-of-function of MeCP2 causes Rett syndrome (RTT) and MECP2 duplication syndrome (MDS), respectively. MeCP2 binds methyl-cytosines to finely tune gene expression in the brain, though identifying genes robustly regulated by MeCP2 has been difficult. By integrating multiple transcriptomics datasets, we identified that MeCP2 finely regulates Growth differentiation factor 11 ( Gdf11)....

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Literature Corpus work: e7bd4894-e922-58bd-a20c-32127d3d7d32
DOI: 10.1101/2022.10.05.510925

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