Article

Loss of Dnmt3a dependent methylation in inhibitory neurons impairs neural function through a mechanism that impacts Rett syndrome

2019-10-22

Abstract excerpt

Methylated cytosine is an effector of epigenetic gene regulation. In the mammalian brain, the DNA methyltransferase, Dnmt3a, is the sole “writer” of atypical non-CpG methylation (mCH), and methyl CpG binding protein 2 (MeCP2) is the only known “reader” for mCH. We set out to determine if MeCP2 is the sole reader for Dnmt3a dependent methylation by comparing mice lacking either Dnmt3a or MeCP2 in GABAergic inhibito...

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Literature Corpus work: a31833a8-ddee-5c1a-88e3-8bf9c29ee52f
DOI: 10.1101/815639

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