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Article

DNA methylation, nucleic acid structure, and rett mutations tune MeCP2 binding affinity and cooperativity.

The Journal of biological chemistry - 1 Jul 2026

Melikishvili Manana, Rea Matthew, Capan Colt, Lee Hyoungjoo, Chandler Darrell P, Fondufe-Mittendorf Yvonne N

Abstract excerpt

Methyl-CpG-binding protein 2 (MeCP2) is a chromatin-associated factor whose dysfunction causes Rett syndrome. Although MeCP2 preferentially binds methylated DNA, its affinity for methylated substrates is only ∼ threefold higher than for unmethylated DNA, raising the question of how MeCP2 selectively recognizes its targets. Here, we quantify binding of full-length WT MeCP2 and Rett-associated variants (R106W,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42248459
DOI: 10.1016/j.jbc.2026.113227
PMCID: PMC13333338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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