Article

Genetically Predicted Thyroid-Stimulating Hormone and Coronary Artery Disease: Lipid-Mediated Causal Pathways, PCSK9 Protein Validation, and a Suppression Effect Revealed by Multi-Layered Mendelian Randomization

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>Background Subclinical hypothyroidism (SCH) affects 4–10% of the general population and has been inconsistently linked to coronary artery disease (CAD). Whether thyroid-stimulating hormone (TSH) causally influences CAD risk, and through which biological pathways, remains unresolved. We conducted a multi-layered Mendelian randomization (MR) study integrating mediation analysis, proteomi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6c95863f-b505-509e-a4cc-62a5a3618f50
DOI: 10.21203/rs.3.rs-9273655/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetically Predicted Thyroid-Stimulating Hormone and Coronary Artery Disease: Lipid-Mediated Causal Pathways, PCSK9 Protein Validation, and a Suppression Effect Revealed by Multi-Layered Mendelian RandomizationDOI 10.21203/rs.3.rs-9273655/v1Read

Bidirectional 2-sample Mendelian randomization study of the causal relationship between hypothyroidism and cardiovascular diseases.Semantic proximity Read

Novel insights into causal effects of lipid and lipid-lowering targets with autoimmune thyroid disease: A Mendelian randomization studySemantic proximity Read

The causal effects of hypothyroidism on cardiovascular disease: Bidirectional and multivariable Mendelian randomization study.Semantic proximity Read

Thyroid Function and Metabolic Syndrome: A Two-Sample Bidirectional Mendelian Randomization StudySemantic proximity Read

Higher thyrotropin leads to unfavorable lipid profile and somewhat higher cardiovascular disease risk: evidence from multi-cohort Mendelian randomization and metabolomic profilingSemantic proximity Read

Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits.Semantic proximity Read

Genetically predicted hypothyroidism, thyroid hormone treatment, and the risk of cardiovascular diseases: a mendelian randomization study.Semantic proximity Read

Mendelian Randomization Highlights the Causal Role of Normal Thyroid Function on Blood Lipid Profiles.Semantic proximity Read

A factorial Mendelian randomization study to systematically prioritize genetic targets for the treatment of cardiovascular diseaseSemantic proximity Read

Causal Association of Thyroid Signaling with C-Reactive Protein: A Bidirectional Mendelian Randomization.Semantic proximity Read

Epigenetic Regulation of ITGB7 Promotes Coronary Heart Disease via Immune and Metabolic Pathways: A Multimodal Mendelian Randomization Study.Semantic proximity Read

COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study.Semantic proximity Read