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Distinct Evolutionary Trajectories in Early Lung Adenocarcinoma: Age-Related Pathway with Epidermal Growth Factor Receptor–Associated Genome Doubling and Smoking-Driven Pathway

2026-07-23

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> Lung adenocarcinoma a progress from preinvasive lesions to invasive cancer; however, early evolutionary events in adenocarcinoma in situ (AIS) and minimally invasive adenocarcinoma (MIA) remain poorly defined, particularly in East Asian populations enriched for EGFR mutations. We performed whole-exome sequencing on 67 Japanese patients (38 AIS, 29 MIA), including multiregion sampling i...

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Literature Corpus work: 717e188b-00de-53be-964b-4efe51a6fec6
DOI: 10.64898/2026.07.21.26358543

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