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Article

Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma.

Nature communications - 27 Nov 2020

Wang Siwei, Du Mulong, Zhang Jingyuan, Xu Weizhang, Yuan Qianyu, Li Ming, Wang Jie, Zhu Hongyu, Wang Yuzhuo, Wang Cheng, Gong Yuhua, Wang Xiaonan, Hu Zhibin, Christiani David C, Xu Lin, Shen Hongbing, Yin Rong

Abstract excerpt

The evolutionary trajectories of early lung adenocarcinoma (LUAD) have not been fully elucidated. We hypothesize that genomic analysis between pre-invasive and invasive components will facilitate the description of LUAD evolutionary patterns. We micro-dissect malignant pulmonary nodules (MPNs) into paired pre-invasive and invasive components for panel-genomic sequencing and recognize three evolutionary...

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Identifiers

PMID: 33247113
DOI: 10.1038/s41467-020-19855-x
PMCID: PMC7695730

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