Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct mutational features across preinvasive and invasive subtypes identified through comprehensive profiling of surgically resected lung adenocarcinoma.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2022

Xiang Chan, Ji Chunyu, Cai Yiran, Teng Haohua, Wang Yulu, Zhao Ruiying, Shang Zhanxian, Guo Lianying, Chen Shengnan, Lizaso Analyn, Lin Jing, Wang Haozhe, Li Bing, Zhang Zhou, Zhao Jikai, Wei Jinzhi, Liu Jiaxin, Zhu Lei, Fang Wentao, Han Yuchen

Abstract excerpt

Lung adenocarcinoma (LUAD) is a heterogeneous disease. Our study aimed to understand the unique molecular features of preinvasive to invasive LUAD subtypes. We retrospectively analyzed the clinical, histopathological, and molecular data of 3,254 Chinese patients with preinvasive lesions (n = 252), minimally invasive adenocarcinomas (n = 479), and invasive LUAD (n = 2,523). Molecular data were elucidated using a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenocarcinoma of Lung

Share to Carcinogenesis

Share to Lung Neoplasms

Share to Mutation

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 35641658
DOI: 10.1038/s41379-022-01076-w
PMCID: PMC9424111

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct mutational features across preinvasive and invasive subtypes identified through comprehensive profiling of surgically resected lung adenocarcinoma.PMID 35641658Read ↗

Genomic signature driving preinvasive to invasive processes in stage I lung adenocarcinoma.Semantic proximity Read ↗

Genetic Alterations in Preinvasive Lung Synchronous Lesions.Semantic proximity Read ↗

Comparison of gene mutation profile in different lung adenocarcinoma subtypes by targeted next-generation sequencing.Semantic proximity Read ↗

Comparative study on the mutational profile of adenocarcinoma and squamous cell carcinoma predominant histologic subtypes in Chinese non-small cell lung cancer patients.Semantic proximity Read ↗

Clinicopathological and molecular characterization of resected lung adenocarcinoma: Correlations with histopathological grading systems in Chinese patients.Semantic proximity Read ↗

Whole-genome sequencing reveals the molecular implications of the stepwise progression of lung adenocarcinoma.Semantic proximity Read ↗

Tumor evolutionary trajectories during the acquisition of invasiveness in early stage lung adenocarcinoma.Semantic proximity Read ↗

Distinct Evolutionary Trajectories in Early Lung Adenocarcinoma: Age-Related Pathway with Epidermal Growth Factor Receptor–Associated Genome Doubling and Smoking-Driven PathwaySemantic proximity Read ↗

Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.Semantic proximity Read ↗

Pulmonary Adenocarcinoma In Situ and Minimally Invasive Adenocarcinomas in European Patients Have Less KRAS and More EGFR Mutations Compared to Advanced Adenocarcinomas.Semantic proximity Read ↗

Genomic and Transcriptomic Dynamics in the Stepwise Progression of Lung AdenocarcinomaSemantic proximity Read ↗

EGFR and ERBB2 Exon 20 Insertion Mutations in Chinese Non-small Cell Lung Cancer Patients: Pathological and Molecular Characterization, and First-Line Systemic Treatment Evaluation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.