Article

NCOR2 represses MHC class I molecule expression to drive metastatic progression of breast cancer

2025-03-12

Abstract excerpt

<h4>ABSTRACT</h4> Metastatic progression depends upon the ability of disseminated tumor cells to evade immune surveillance. MHC molecule expression facilitates T cell recognition and activation to permit the eradication of metastatic tumor cells. We identified nuclear corepressor 2 (NCOR2) as a key epigenetic regulator of MHC class I molecule expression on breast tumor cells. Patients with triple negative breast...

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Literature Corpus work: 7168a3f5-d26e-51be-aa85-4acdc056a1ad
DOI: 10.1101/2025.03.10.642060

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