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Article

Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer.

Cell reports - 21 Jan 2020

Yomtoubian Shira, Lee Sharrell B, Verma Akanksha, Izzo Franco, Markowitz Geoffrey, Choi Hyejin, Cerchietti Leandro, Vahdat Linda, Brown Kristy A, Andreopoulou Eleni, Elemento Olivier, Chang Jenny, Inghirami Giorgio, Gao Dingcheng, Ryu Seongho, Mittal Vivek

Abstract excerpt

Epigenetic changes are increasingly being appreciated as key events in breast cancer progression. However, breast cancer subtype-specific epigenetic regulation remains poorly investigated. Here we report that EZH2 is a leading candidate of epigenetic modulators associated with the TNBC subtype and that it predicts poor overall survival in TNBC patients. We demonstrate that specific pharmacological or genetic...

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PMID: 31968251
DOI: 10.1016/j.celrep.2019.12.056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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