Article

E2F1 Drives Breast Cancer Metastasis by Regulating the Target Gene FGF13 and Altering Cell Migration

2019-06-13

Abstract excerpt

<h4>ABSTRACT</h4> In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis. Here we address the mechanisms for this phenotype and identify the E2F regulated genes that coordinate tumor cell metastasis. Transcriptomic profiling of E2F1 knockout tumors identified a role for E2F1 as a master regulator of a suite of pro-metastatic genes, but also uncovered E2F1 target genes with an unk...

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Literature Corpus work: b6b0c44b-8319-519d-941c-122329d3a40c
DOI: 10.1101/671149

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