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Article

Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.

Cancer research - 15 Oct 2018

Zhang Fang-Lin, Cao Jin-Ling, Xie Hong-Yan, Sun Rui, Yang Li-Feng, Shao Zhi-Ming, Li Da-Qiang

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most lethal subtype of breast cancer, with a high propensity for distant metastasis and limited treatment options, yet its molecular underpinnings remain largely unknown. Microrchidia family CW-type zinc finger 2 (MORC2) is a newly identified chromatin remodeling protein whose mutations have been causally implicated in several neurologic disorders. Here, we report that...

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Identifiers

PMID: 30093560
DOI: 10.1158/0008-5472.CAN-17-1394

Genes

MORC2

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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