Article

Breast cancer progression and metastasis to lymph nodes reveals cancer cell plasticity and MHC class II-mediated immune regulation

2022-11-01

Abstract excerpt

<h4>Summary</h4> Tumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells and are associated with durable immune responses. However, lymph nodes are often the first site of metastasis and lymph node metastases portend worse outcomes. Through cross-species single cell gene expression analysis of breast cancer progression and metastasis to lymph nodes, we uncovered features that d...

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Literature Corpus work: 0355c209-c5f4-5723-9b83-bb42c2361048
DOI: 10.1101/2022.10.30.514441

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