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Article

HIC1 silencing in triple-negative breast cancer drives progression through misregulation of LCN2.

Cancer research - 1 Feb 2014

Cheng Guangcun, Sun Xueqing, Wang Jinglong, Xiao Gang, Wang Xiumin, Fan Xuemei, Zu Lidong, Hao Mingang, Qu Qing, Mao Yan, Xue Yunjing, Wang Jianhua

Abstract excerpt

The tumor suppressor gene HIC1 is frequently deleted or epigenetically silenced in human cancer, where its restoration may improve cancer prognosis. Here, we report results illuminating how HIC1 silencing alters effect or signals in triple-negative breast cancer (TNBC), which are crucial for its pathogenesis. HIC1 expression was silenced only in TNBC compared with other molecular subtypes of breast cancer....

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Source

Identifiers

PMID: 24295734
DOI: 10.1158/0008-5472.CAN-13-2420

Genes

HIC1
LCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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