Article

Similar and different: systematic investigation of proteogenomic variation between sexes and its relevance for human diseases

2024-02-18

Abstract excerpt

To better understand sex differences in human health and disease, we conducted a systematic, large-scale investigation of sex differences in the genetic regulation of the plasma proteome (>5,000 targets), including their disease relevance. Plasma levels of two-thirds of protein targets differed significantly by sex. In contrast, genetic effects on protein targets were remarkably similar, with very few protein quan...

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Literature Corpus work: 716563ea-a64c-522f-b90d-9b74afc7595c
DOI: 10.1101/2024.02.16.24302936

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