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Factors Governing B Cell Recognition of Autoantigen and Function in Type 1 Diabetes

1 Apr 2024

Abstract excerpt

Islet autoantibodies predict type 1 diabetes (T1D) but can be transient in murine and human T1D and are not thought to be directly pathogenic. Rather, these autoantibodies signal B cell activity as antigen-presenting cells (APCs) that present islet autoantigen to diabetogenic T cells to promote T1D pathogenesis. Disrupting B cell APC function prevents T1D in mouse models and has shown promise in clinical trials....

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PMID: 38651407
DOI: 10.3390/antib13020027

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