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Article

HLA-B*39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2018

Schloss Jennifer, Ali Riyasat, Racine Jeremy J, Chapman Harold D, Serreze David V, DiLorenzo Teresa P

Abstract excerpt

Type 1 diabetes (T1D) is characterized by T cell-mediated destruction of the insulin-producing β cells of the pancreatic islets. Among the loci associated with T1D risk, those most predisposing are found in the MHC region. HLA-B*39:06 is the most predisposing class I MHC allele and is associated with an early age of onset. To establish an NOD mouse model for the study of HLA-B*39:06, we expressed it in the...

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Share to CD8-Positive T-Lymphocytes
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class I

Share to HLA-A2 Antigen

Share to HLA-B Antigens

Share to Insulin-Secreting Cells

Share to Mice, Inbred NOD

Share to Thymus Gland

Source

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Identifiers

PMID: 29632144
DOI: 10.4049/jimmunol.1701652
PMCID: PMC5940557

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