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Article

The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8(+) T cells to respond to foreign antigens.

Nature immunology - 1 Jan 2015

Fulton Ross B, Hamilton Sara E, Xing Yan, Best J Adam, Goldrath Ananda W, Hogquist Kristin A, Jameson Stephen C

Abstract excerpt

The strength with which complexes of self peptide and major histocompatibility complex (MHC) proteins are recognized by the T cell antigen receptor (TCR) dictates the homeostasis of naive CD8(+) T cells, but its effect on reactivity to foreign antigens is controversial. As expression of the negative regulator CD5 correlates with self-recognition, we studied CD5(lo) and CD5(hi) naive CD8(+) T cells....

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Identifiers

PMID: 25419629
DOI: 10.1038/ni.3043
PMCID: PMC4270846

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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