Article

Traumatic brain injury in mice generates early-stage Alzheimer’s disease related protein pathology that correlates with neurobehavioral deficits

2023-05-05

Abstract excerpt

<title>Abstract</title> <p>Traumatic brain injury (TBI) increases the long-term risk of neurodegenerative diseases, including Alzheimer’s disease (AD). Here, we demonstrate that protein variant pathology generated in brain tissue of an experimental TBI mouse model is similar to protein variant pathology observed in human ADbrains, and that subacute accumulation of two AD associated variants of amyloid beta (Aβ) a...

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Literature Corpus work: 7126cbfd-52e0-5611-856d-5320bab45503
DOI: 10.21203/rs.3.rs-2865501/v1

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