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Common mouse models of tauopathy reflect early but not late human disease

2 Feb 2023

Abstract excerpt

BACKGROUND: Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer's Disease (AD) and while several drugs showed therapeutic effects in these mice, they were ineffective in humans. This leads to the question to which extent the murine models reflect human Tau pathology on the molecular level. METHODS: We isolated insoluble, aggregated Tau species...

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PMID: 36732784
DOI: 10.1186/s13024-023-00601-y

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